Use of the drug Fungin Forte for the treatment of skin diseases in cats

Composition and release form

The drug is a liquid whose color is usually light or dark yellow. It is packaged in glass or polymer bottles. Their volume can vary - from 10 to 50 ml. Polymer packages can be equipped with a spray head. The spray is considered more convenient to use, especially when the epidermis is damaged in large areas, but the composition of the medicinal solution remains unchanged.

High efficiency is ensured by a complex of active components. Fungin Forte contains:

• terbinafine;
• dexamethasone;
• metronidazole;
• lidocaine.

Auxiliary components are:

• polyethylene glycol;
• benzyl alcohol;
• dimethyl sulfoxide;
• orange terpene.

Compound

The medicine was developed by the Moscow company Api-San in 2015. It is considered an effective antifungal agent for the treatment of skin pathologies in pets. Spray "Fungin Forte" has a more advanced formula than just "Fungin", made by the same company before.

One milliliter of the drug contains the following active ingredients:

• 10 mg terbinafine hydrochloride;
• 10 mg thiabendazole;
• 10 mg metronidazole;
• 50 mg lidocaine hydrochloride;
• 1 mg dexamethasone sodium phosphate.

In addition, the medicine contains the following auxiliary components:

• 10% propolis tincture – 50 mg;
• dimethyl sulfoxide – 100 mg;
• orange terpene – 5 mg;
• benzyl alcohol – 300 mg;
• polyethylene glycol-400 - up to 1 milliliter.

Pharmacological properties

The main advantage of the drug is its wide spectrum of action, which is determined by the active components. It is effective in destroying fungi of various types, helps restore skin and hair, which usually falls out in places where the disease develops.

Each of the active components has its own effect:

1. Terbinafine has antifungal properties. The principle of its action is to block the enzyme necessary for the life and development of fungi. The absence of the enzyme leads to their rapid death. The substance practically does not penetrate into the bloodstream, but can accumulate in the sebaceous glands and hair follicles.
2. Thiabendazole has pronounced fungicidal (antifungal) properties. It not only contributes to the disruption of metabolic processes in fungi, which leads to death, but also destroys the reproductive ability, due to which they cannot reproduce.
3. Metronidazole has an antibacterial effect. It is effective even against the simplest microorganisms, which can pose a serious danger to animals and people.
4. Dexamethasone is a synthetic glucocorticosteroid that has a broad spectrum of action. Suppresses inflammatory processes, has immunosuppressive, antiallergic and antitoxic effects.
5. Lidocaine reduces pain by suppressing the sensitivity of nerve endings.

The medicine promotes wound healing and hair restoration, as it triggers regenerative processes.

Indications for use

Fungin Forte is prescribed for cats in the treatment of the following pathologies:

• trichophytosis;
• seborrheic dermatitis;
• eczema of fungal etiology;
• ringworm;
• other fungal skin diseases.

The drug can be used only after a diagnosis has been made. If you have symptoms of a fungal infection, you should consult a doctor and get tested. Do not try to self-medicate. And remember that fungal diseases can be transmitted to humans.

Instructions for use

When using Fungin Forte for cats, be sure to follow the instructions for use. You need to do the following:

1. Provide maximum access to the skin. Trim the fur if necessary.
2. If you are using a spray, spray it on the areas where the fungus is located. If you use liquid, apply it to the epidermis using a cotton-gauze swab. Apply the product in a thin layer.
3. When applying the medicine, also cover the healthy area around the affected area (step back 1 cm from the edge). This will help prevent further spread of the disease.
4. Rub the medication into the skin with light movements.

The procedure must be repeated 1-2 times a day, depending on the degree of infection and the severity of the disease. The drug should be used until the clinical signs of the pathology completely disappear, but not more than 15 days. After the course of treatment, you should definitely submit scrapings for research to confirm the absence of fungi.

With severe development of the disease, Fungin Forte can be used in combination with other medications. They should be prescribed exclusively by a doctor.

Spray for animals Apicenna Fungin Forte (treatment of lichen and other fungal diseases)

General information:

Trade name of the drug: Fungin Forte. International nonproprietary name: terbinafine, thiabendazole, metronidazole, lidocaine, dexamethasone.

Dosage form: solution for external use. Fungin Forte in 1 ml contains as active substance: terbinafine hydrochloride - 10 mg, thiabendazole - 10 mg, metronidazole - 10 mg, lidocaine hydrochloride - 50 mg, dexamethasone sodium phosphate - 1 mg, and as excipients: benzyl alcohol - 300 mg, dimethyl sulfoxide - 100 mg, orange terpene - 5 mg and polyethylene glycol-400 - up to 1 ml. In appearance, the drug is a solution from light yellow to dark yellow.

Fungin Forte is produced in glass bottles of 10, 12 and 15 ml, sealed with rubber stoppers with aluminum caps; in polymer bottles with mechanical spray heads of 20, 30, 40 and 50 ml or in polymer bottles with dropper caps with first opening control of 10, 12 and 15 ml. Each consumer package is supplied with instructions for use.

Store the drug in the manufacturer's sealed packaging, separate from food and feed, in a dry place, protected from direct sunlight, at a temperature from 0°C to 25°C. The shelf life of Fungin Forte, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of production, after opening the bottle - 30 days. Do not use Fungin Forte after the expiration date.

Fungin Forte should be stored out of the reach of children.

Unused medicinal product is disposed of in accordance with legal requirements.

Pharmacological properties

Fungin Forte belongs to combined antimicrobial drugs. Terbinafine is an antifungal agent of the allylamine group, active against pathogens of animal dermatomycosis. The mechanism of action is to inhibit squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes the death of the pathogen cell. Depending on the concentration, terbinafine exhibits a fungicidal or fungistatic effect.

Due to its high lipophilicity, terbinafine molecules accumulate in the stratum corneum of the dermis, hair follicles, and sebaceous glands; When applied topically, the drug penetrates into the systemic circulation to a small extent.

Thiabendazole is a fungicide from the azole class. Active against pathogens of trichophytosis and microsporia of animal genera Trichophyton, Microsporum, Epidermophyton, Achorion. Like other azoles, it blocks the activity of enzymes involved in 14-demethylation of lanosterol, which leads to disruption of ergosterol synthesis. A change in the structure of the cytoplasmic membrane of fungal cells leads to a disruption of its permeability, the release of biologically active substances from the cell and the destruction of the cell wall. In addition, thiabendazole disrupts the process of nuclear division and inhibits the reproductive ability of fungi.

Metronidazole is a drug from the group of nitroimidazoles. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the bacterial cell, inhibiting the synthesis of nucleic acids in it, which leads to the death of the microorganism.

Dexamethasone is a synthetic glucocorticosteroid, a methylated derivative of fluoroprednisolone. It has anti-inflammatory, antiallergic, desensitizing, immunosuppressive, antishock and antitoxic effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines.

The mechanism of action of dexamethasone is to suppress the activity of various tissue-destructive enzymes - proteases and nucleases, matrix metalloproteinases, hyaluronidase, phospholipase, inhibition of the synthesis of prostaglandins, kinins, leukotrienes and other inflammatory mediators from arachidonic acid.

Lidocaine - has a local anesthetic effect, blocks voltage-gated sodium channels, which prevents the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers.

In terms of the degree of impact on the body, Fungin Forte is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76); in recommended doses it does not have a local irritant, resorptive-toxic or sensitizing effect. In case of contact with eyes, it causes mild irritation.

Application procedure:

Fungin Forte is prescribed to dogs and cats for the treatment of fungal skin diseases, eczema of fungal etiology and seborrheic dermatitis.

Contraindication for use is the animal's hypersensitivity to the components of the drug. Weakened animals, lactating and pregnant females, as well as puppies and kittens under 4 weeks of age cannot be treated.

Fungin Forte is applied in a thin layer using a cotton-gauze swab, as well as by spraying or applying directly to the skin from a dropper bottle, lightly rubbing into the affected areas from the periphery to the center, covering up to 1 cm of borderline healthy skin. Treatments are carried out once or twice a day until clinical recovery, but not more than 15 days, which is confirmed by microscopic examination of skin scrapings.

To prevent licking of the drug, animals are put on a muzzle, a collar, or the jaws are closed with a loop of braid, which are removed 15–20 minutes after treatment. In severe cases of the disease, animals are additionally prescribed drugs for specific and symptomatic therapy in accordance with the instructions for use.

No overdose symptoms were identified.

No peculiarities of action were identified during the first use of the drug and when it was discontinued.

If the next treatment is missed, the use of the drug is resumed at the same dose, according to the same regimen.

There are no side effects or complications when using the drug Fungin Forte according to these instructions. If the animal’s individual sensitivity to the components of the drug is increased and signs of skin irritation appear, the treatment is stopped, Fungin Forte is removed with a swab and washed off with water, the animal is prescribed antihistamines and symptomatic therapy.

Fungin Forte should not be used simultaneously with other topical preparations containing corticosteroid hormones.

Fungin Forte is not intended for use in food producing animals.

Prevention measures

When working with Fungin Forte, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicinal products. After finishing work, wash your hands with warm water and soap.

In case of accidental contact of the drug with the skin or mucous membranes of the eye, they should be immediately rinsed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with Fungin Forte. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug and the label).

Empty drug bottles must not be used for household purposes; they must be disposed of with household waste.

special instructions

When using the medication, it is important to follow a number of simple rules:

1. Do not allow animals to lick the drug. A cervical collar is well suited for these purposes. The protection should be removed only after the liquid has completely dried.
2. If the solution does get into your pet's stomach, give activated charcoal and drink water, and then contact your veterinarian.
3. If there are several pets living in a house, a sick cat should be isolated.
4. The medicine can be used to treat fungus on the face. Be careful not to get the liquid into your eyes, as it will irritate your mucous membranes.
5. Carry out the processing procedure only with rubber or latex gloves. When finished, wash your hands thoroughly with soap and warm water.
6. During the period of using the medicine, bathing should be avoided, as water procedures can reduce the effectiveness of the product.
7. Follow the treatment regimen recommended by your doctor and do not skip procedures. If it was not possible to carry out the processing on time, correct the situation as soon as possible, and then return to the applied scheme.

Remember that ringworm is transmitted to humans, so limit the animal’s contact with children during the treatment period.

Contraindications and side effects

And although the medicine is a low-hazard substance, it is prohibited for some categories of animals. Contraindications are:

• intolerance to components;
• pregnancy;
• lactation period;
• exhaustion;
• recovery after serious illnesses;
• age up to 1 month.

Active components are excreted through the liver and kidneys. It is imperative to consult a doctor in case of chronic diseases of these organs or disturbances in their functioning.

Fungin Forte is usually well tolerated by kittens (from one month of age) and adult cats. The instructions indicate that it does not cause side effects. If you have intolerance to the components, unpleasant symptoms may occur:

• irritation of the epidermis;
• itching;
• rashes;
• nausea and vomiting;
• stomach upset;
• other allergic reactions.

Observe the animal carefully after the first application of the medication. If undesirable reactions occur, wash off the medicine with water and detergent (shampoo or soap). Contact your veterinarian. Depending on your pet's condition, you may need to take antihistamines. Fungin Forte is replaced with other medications.

Contraindications

Like any medicine, Fungin Forte spray has a number of contraindications:

• individual intolerance to one of the components included in the composition;
• period of pregnancy and lactation;
• state of exhaustion;
• rehabilitation after serious illnesses;
• puppies and kittens up to one month old.

The active substances are excreted through the kidneys and liver. In this regard, if you have diseases of these organs, you should consult a specialist before use.

Storage rules

The effectiveness of the drug depends on proper storage. And although there are no special requirements for storing Fungin Forte, follow a number of simple recommendations. The storage location should be away from animal feed and food. It is important that children do not have access to it.

The temperature should be between 0 and 25˚C. The medication should be kept out of reach of sunlight. If the drug in an open bottle has not been used within 30 days, it must be disposed of in accordance with the law.

Basic information

A fungicidal drug whose active ingredient is clotrimazole. It is packaged in glass bottles of 10-15 and 30 milliliters, which, in turn, are packaged in cardboard boxes. In addition, in the last couple of years, polymer bottles with a capacity of 20/30/40 and 50 milliliters have appeared. The “glass” version is sealed with rubber stoppers and aluminum lids; the “plastic” version has a convenient spray head.

Each package must be labeled with the name of the medicine, batch number and expiration date. It is strictly prohibited to use this medicine after the warranty period has expired!

Owner reviews

Olesya, owner of a Persian cat:

“Our handsome guy caught shingles somewhere. For treatment, the veterinarian prescribed Fungin. I bought a spray at the pharmacy. Already on the fifth day of use, hair began to grow in the affected areas. The drug is effective, however, after a while there was a relapse. On the advice of a friend, I used Clotrimazole ointment. It is as effective as a spray, but the price is significantly lower.”

Oksana, owner of a 2-year-old cat:

“On the doctor’s recommendation, I used the drug to treat lichen in a cat. The animal became restless, so we had to abandon further use. Afterwards I used sulfur ointment. I didn’t notice any difference in effectiveness, but Miki tolerated the treatment calmly.”

Elena, owner of a 2-month-old kitten:

“Good drug. Used to treat ringworm in a kitten. Used for 10 days. From the 7th day the fur began to recover. No side effects were found. The kitten was indifferent to the procedures.”